The Red Cross will pull some members of its humanitarian team out of Syria, the group announced on Friday.
"Some of the International Committee of the Red Cross team will move to Beirut in the next two days," said ICRC spokesman Hicham Hassan, adding that 50 international and local staff would remain in Damascus, the capital.
Damascus is the only place where the Geneva-based humanitarian organisation maintains a presence, while the Syrian Arab Red Crescent mostly operates in the northern city of Aleppo.
Fears are mounting that the regime is planning a major offensive on Aleppo, Syria's largest city, where rebels have infiltrated over the past two weeks.
World powers are warning of a possible massacre in the city and calling for maximum pressure on President Bashar al-Assad to prevent it.